The decision to treat is based on cytopenias especially if symptomaticincreasing splenomegaly, indications that the disease is progressing, or the presence of other, usually infectious, complications. Therefore, because a number of more effective alternatives are available, splenectomy is playing a decreasing role in the treatment of this disease. The characteristic cytoplasmic projections are already visible. T lymphocytes that help B lymphocytes make antibodies to help fight infection.
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